@import url('https://fonts.googleapis.com/css2?family=Inter:wght@400;500;600;700;800&display=swap');
:root{--blue:#1b498c;--dark:#123565;--cyan:#02a3da;--ink:#20344b;--muted:#526577;--line:#dce5ed;--pale:#edf5fb;--white:#fff;--gold:#94721c}*{box-sizing:border-box}html{scroll-behavior:smooth;scroll-padding-top:110px}body{margin:0;color:var(--ink);font-family:Inter,Arial,sans-serif;font-size:16px;line-height:1.75}::selection{background:#b9e8f7;color:var(--dark)}a{color:var(--blue);text-underline-offset:4px}button,a{-webkit-tap-highlight-color:transparent}button{font:inherit}a:focus-visible,button:focus-visible,summary:focus-visible{outline:3px solid #b88b17;outline-offset:5px}button,a,summary{touch-action:manipulation}.wrap{width:min(1180px,calc(100% - 64px));margin-inline:auto}.prototype{background:var(--dark);color:#fff;text-align:center;font-size:12px;padding:7px 20px;letter-spacing:.015em}.prototype span{padding:0 10px;color:#8fcbef}header{background:#fff;position:sticky;top:0;z-index:10;border-bottom:1px solid var(--line)}.header-inner{width:min(1320px,calc(100% - 64px));margin:auto;min-height:94px;display:flex;align-items:center;justify-content:space-between;gap:28px}.logo{width:222px;height:auto;display:block}nav{display:flex;gap:25px;align-items:center}header nav a{font-size:12px;font-weight:600;text-decoration:none;white-space:nowrap}header nav a:hover{color:#0879a3}.button{background:var(--blue);color:#fff;display:inline-flex;align-items:center;justify-content:center;gap:24px;padding:13px 22px;text-decoration:none;font-size:13px;font-weight:600;border-radius:5px;min-height:48px;transition:background .2s}.button:hover{background:var(--dark);color:#fff}.button span[aria-hidden]{font-size:20px;line-height:1}.button.compact{font-size:12px;padding:10px 15px;gap:13px;min-height:44px}.menu-toggle{display:none}.hero{background:var(--pale)}.hero-grid{display:grid;grid-template-columns:1.15fr 1fr;gap:60px;padding-top:40px;padding-bottom:55px;align-items:center}.breadcrumb{font-size:12px;color:var(--muted);display:flex;gap:12px;margin-bottom:30px}.breadcrumb a{text-decoration:none}h1{font-size:clamp(38px,4.1vw,60px);line-height:1.12;letter-spacing:-.035em;color:var(--blue);margin:0 0 25px;font-weight:800}h1 span{font-weight:500;color:var(--dark)}.hero-copy>p{font-size:16px;line-height:1.8;max-width:49ch;margin:0 0 28px}.hero-link{display:inline-block;margin-left:20px;font-size:12px;text-decoration:none;font-weight:600}.science-plate{position:relative;padding:0 15px;color:var(--blue)}.molecule{width:100%;aspect-ratio:480/330}.molecule svg{width:100%;height:100%}.bonds{fill:none;stroke:#aac8df;stroke-width:7;stroke-linejoin:round}.atoms{fill:var(--blue);stroke:#edf5fb;stroke-width:5}.atoms circle:nth-child(2n){fill:#02a3da}.satellites{fill:#88bedb;stroke:#edf5fb;stroke-width:3}.plate-caption{display:flex;align-items:center;gap:9px;font-size:12px;justify-content:center}.legend-dot{width:7px;height:7px;border-radius:50%;background:var(--blue)}.legend-line{width:20px;height:2px;background:#8baccc;margin-left:14px}.plate-note{font-size:20px;line-height:1.45;letter-spacing:-.025em;margin-top:28px;text-align:center}.science-plate>small{display:block;font-size:12px;color:var(--muted);text-align:center;margin-top:13px}.hero-bottom{border-top:1px solid #cddfea;display:flex;justify-content:space-between;padding-top:14px;padding-bottom:14px;color:var(--muted);font-size:12px}.hero-bottom a{text-decoration:none;font-weight:600}.content-layout{display:grid;grid-template-columns:225px minmax(0,1fr);gap:75px;padding-top:65px;padding-bottom:80px}.page-index{align-self:start;position:sticky;top:130px;font-size:12px}.page-index>p{font-weight:700;margin:0 0 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button{background:none;border:0;border-bottom:3px solid transparent;color:var(--muted);font-size:13px;padding:12px 0;cursor:pointer}.tabs button[aria-selected=true]{border-bottom-color:var(--blue);color:var(--blue);font-weight:700}.classification{margin:0 0 12px}.classification>div{display:grid;grid-template-columns:100px 1fr 110px;gap:15px;padding:23px 0;border-bottom:1px solid var(--line);align-items:center}.classification dt{font-size:14px;font-weight:700;color:var(--dark)}.classification dd{margin:0;font-size:13px;color:var(--muted);line-height:1.7}.chain{display:flex;gap:6px;align-items:center;justify-content:center}.chain i{height:10px;width:10px;border-radius:50%;background:var(--cyan);position:relative}.chain i:after{content:'';position:absolute;top:4px;left:10px;width:6px;height:2px;background:#8baccc}.chain i:last-child:after{display:none}.chain.cyclic{height:45px;position:relative}.cyclic i{position:absolute;left:50%;top:50%;transform:rotate(calc(var(--i)*72deg)) translate(18px) rotate(calc(var(--i)*-72deg));width:9px;height:9px}.cyclic i:nth-child(1){--i:0}.cyclic i:nth-child(2){--i:1}.cyclic i:nth-child(3){--i:2}.cyclic i:nth-child(4){--i:3}.cyclic i:nth-child(5){--i:4}.cyclic i:after{display:none}small{font-size:12px;color:var(--muted)}.approval{background:#f0f6fb;padding:32px;border-radius:12px}.status{font-size:12px;color:#655318;background:#f7efd7;display:inline-flex;gap:8px;align-items:center;padding:5px 10px;margin-bottom:20px;border-radius:4px;line-height:1.5}.status>span{width:6px;height:6px;border-radius:50%;background:#94721c;flex-shrink:0}.verify{border-top:1px solid #cedfea;padding-top:22px;margin-top:24px}.verify ul{font-size:13px;margin:0 0 24px;padding-left:20px}.text-link{font-size:12px;font-weight:600}.verify>.text-link{margin-left:20px;display:inline-block}.notice{background:#fff8e8;padding:27px;display:flex;gap:20px;border-radius:12px}.notice>svg{width:25px;height:25px;flex-shrink:0;stroke:#926c18;fill:none;stroke-width:1.6}.notice h2{font-size:19px;color:#6d521d;margin-bottom:12px}.notice p{color:#665a40}.notice p:last-child{margin-bottom:0}.sanctions{border-top:1px solid var(--line);margin-top:25px}details{border-bottom:1px solid var(--line)}summary{padding:17px 25px 17px 0;color:var(--dark);font-size:13px;cursor:pointer;font-weight:700}summary span{font-weight:400;color:var(--muted);float:right;font-size:12px}.sanctions details p{font-size:12px;padding:0 18px 6px}.article .legal-note{font-size:12px;color:var(--muted);margin-top:20px}.report{background:var(--blue);color:#fff;padding:37px;border-radius:12px;position:relative}.report>svg{width:33px;height:33px;fill:none;stroke:#8ed8f4;stroke-width:1.5;margin-bottom:18px}.report h2{color:#fff;font-size:29px}.report p{color:#e3edf9;max-width:62ch}.report .button{background:#fff;color:var(--blue);margin-top:8px}.report .button:hover{background:#d9f2fc}.report small{display:block;color:#d6e5f6;margin-top:16px;font-size:12px}.report small a{color:#fff}.sources{padding-top:15px}.sources h2{font-size:19px}.sources p,.sources li{font-size:12px;line-height:1.8;color:var(--muted)}.sources ol{padding-left:19px}.sources li{margin-bottom:10px}.sources a{text-decoration:none}.sources a:hover{text-decoration:underline}footer{background:#f2f5f8;border-top:1px solid var(--line)}.footer-main{display:flex;align-items:center;gap:45px;padding-top:35px;padding-bottom:35px}.footer-main>img{width:185px;height:auto}.footer-main strong{font-size:12px;color:var(--dark)}.footer-main p{font-size:12px;color:var(--muted);margin:2px 0}.footer-main a{font-size:12px}.back-top{margin-left:auto;text-decoration:none}.footer-bottom{display:flex;justify-content:space-between;border-top:1px solid var(--line);padding-top:13px;padding-bottom:13px;font-size:12px;color:var(--muted)}.sr-only,.skip{position:absolute;width:1px;height:1px;padding:0;margin:-1px;overflow:hidden;clip:rect(0,0,0,0);white-space:nowrap;border:0}.skip:focus{position:fixed;z-index:30;clip:auto;width:auto;height:auto;margin:10px;padding:10px 20px;background:white} [hidden]{display:none!important}
@media(min-width:1000px){.science-plate .atoms{animation:reveal 1s ease-out both}@keyframes reveal{from{opacity:.45}to{opacity:1}}}
@media(max-width:1120px){.header-inner{width:calc(100% - 40px)}nav{gap:16px}.logo{width:180px}.hero-link{margin:15px 0 0;display:block}.hero-grid{gap:25px}.content-layout{gap:45px;grid-template-columns:190px 1fr}}
@media(max-width:900px){.menu-toggle{display:flex;align-items:center;gap:9px;background:white;border:1px solid var(--line);border-radius:4px;padding:8px 12px;font-size:13px;color:var(--blue)}.menu-toggle svg{width:18px;height:18px;fill:none;stroke:currentColor;stroke-width:1.5}.header-inner{min-height:79px;flex-wrap:wrap;gap:0}header nav{display:none;width:100%;padding:10px 0 22px;align-items:stretch;gap:0}header nav.open{display:flex;flex-direction:column}header nav>a{padding:12px 0}header nav>.button{margin-top:10px}.hero-grid{gap:22px}h1{font-size:43px}.content-layout{grid-template-columns:minmax(0,1fr);gap:25px;padding-top:38px}.page-index{position:static}.page-index>p{margin-bottom:12px}.page-index nav{display:flex;overflow-x:auto;gap:22px;padding-bottom:10px;border-top:0}.page-index nav a{flex-shrink:0;padding:7px 0}.index-help{display:none}.article{max-width:780px}.hero-copy>p{font-size:14px}}
@media(max-width:600px){html{scroll-padding-top:90px}.wrap{width:calc(100% - 40px)}.prototype{font-size:12px;line-height:1.5;padding:6px 20px}.prototype span{padding:0 4px}.header-inner{width:calc(100% - 40px);min-height:75px}.logo{width:176px}.hero-grid{display:flex;flex-direction:column;gap:20px;padding-top:22px;padding-bottom:23px}.breadcrumb{margin-bottom:23px;font-size:12px}h1{font-size:43px;line-height:1.12;margin-bottom:21px}.hero-copy{width:100%}.hero-copy>p{font-size:14px;margin-bottom:21px;max-width:42ch}.hero-link{display:inline-block;margin-left:15px;font-size:12px}.hero-copy>.button{font-size:12px;padding:12px 15px;gap:13px}.science-plate{width:100%;max-width:330px;padding:0 10px}.molecule{height:200px}.plate-note{font-size:17px;margin-top:15px}.science-plate>small{font-size:12px;margin-top:8px}.hero-bottom{font-size:12px;gap:15px;align-items:center;padding-block:12px}.hero-bottom>span{max-width:18ch}.content-layout{padding-top:27px;padding-bottom:45px;gap:29px}.page-index{font-size:12px}.page-index nav{gap:20px}.page-index>p{font-size:12px}.article section{margin-bottom:43px;scroll-margin-top:100px}h2{font-size:25px;margin-bottom:18px}.article .lead{font-size:18px}.article p{font-size:13px}.classification>div{grid-template-columns:70px 1fr 65px;gap:10px;padding-block:20px}.classification dd{font-size:12px}.classification dt{font-size:12px}.linear{gap:3px}.linear i{height:8px;width:8px}.linear i:after{left:8px;width:3px;top:3px}.approval{padding:23px 20px}.approval h2{font-size:24px}.status{font-size:12px}.verify>.text-link{margin:14px 0 0;display:block}.notice{padding:22px 18px;gap:13px}.notice>svg{width:21px;height:21px}.notice h2{font-size:19px}summary{font-size:12px;line-height:1.6}summary span{float:none;display:block;padding-left:15px;margin-top:3px}.report{padding:27px 22px}.report h2{font-size:27px}.footer-main{flex-wrap:wrap;gap:18px;padding-block:27px}.footer-main>img{width:163px}.footer-main>div{width:100%}.back-top{margin-left:0}.footer-bottom{display:block;font-size:12px}.footer-bottom span{display:block;margin-bottom:4px}}
@media(prefers-reduced-motion:reduce){html{scroll-behavior:auto}.science-plate .atoms{animation:none}.button{transition:none}}

.content-layout>*{min-width:0}.classification dd{min-width:0}.article p{font-size:16px}.sources p,.sources li,.article .legal-note{font-size:12px}.article .lead{font-size:20px}.page-index nav a{min-height:44px}.page-index nav{scrollbar-color:#91adc8 #edf5fb;scrollbar-width:thin}@media(max-width:600px){.article p{font-size:15px}.article .lead{font-size:18px}.sources p,.sources li,.article .legal-note{font-size:12px}.hero-link{display:block;margin:15px 0 0}.classification>div{grid-template-columns:65px minmax(0,1fr) 55px}.classification dd{font-size:13px}.tabs button{min-height:48px}.hero-copy>p{font-size:15px}}

.arrow{display:inline-block;width:1em;height:1em;vertical-align:-.14em;fill:none;stroke:currentColor;stroke-width:1.8;stroke-linecap:round;stroke-linejoin:round;flex-shrink:0}.button .arrow{width:18px;height:18px}

/* Dorado del texto del menu principal, tomado del sitio oficial ARSA. */
header nav a,header nav a:hover,.menu-toggle{color:#ad8411}header nav .button .arrow{color:#fff}.menu-toggle svg{color:var(--blue)}


/* Clasificacion ampliada por mecanismo de accion. */
.mechanism-title{margin-top:24px}.classification.mechanisms>div{grid-template-columns:minmax(0,1fr);gap:8px}.classification.mechanisms dt{font-size:15px}.classification.mechanisms dd{font-size:14px}.mechanisms+h3{margin-top:28px}
/* Tabla de consulta: limitar estos estilos a la sección de productos. */
.agreement{display:flex;flex-wrap:wrap;align-items:center;justify-content:space-between;gap:24px;padding-block:28px;border-bottom:1px solid var(--line)}
.agreement h2{font-size:20px;margin:0;overflow-wrap:anywhere}
.agreement-actions{display:flex;flex-wrap:wrap;gap:12px;flex-shrink:0}
.agreement-download{background:#fff;color:var(--blue);border:1px solid var(--blue)}
.agreement-preview{width:100%;min-width:0}
.agreement-preview iframe{display:block;width:100%;height:520px;border:1px solid var(--line);border-radius:5px;background:var(--pale)}
.agreement-preview .notice-image{display:block;width:100%;height:auto;border:1px solid var(--line);border-radius:5px}
.agreement-preview p{font-size:12px;color:var(--muted);margin:12px 0}
@media(max-width:700px){.agreement{align-items:flex-start;flex-direction:column;gap:16px}.agreement-actions{width:100%}.agreement-actions .button{flex:1}}
.registry-section{min-width:0}
.article .registry-source{font-size:12px;color:var(--muted);line-height:1.8}
.registry-controls{display:grid;grid-template-columns:minmax(0,2fr) minmax(0,1fr) minmax(0,1.25fr);gap:14px;align-items:end;background:var(--pale);padding:20px;border-radius:12px;margin:25px 0 16px}
.registry-controls>div{min-width:0}
.registry-controls label{font-size:12px;display:block;color:var(--dark);font-weight:600;margin-bottom:7px;line-height:1.5}
.registry-controls input,.registry-controls select{display:block;width:100%;min-height:44px;border:1px solid #b8cadb;border-radius:5px;background:white;padding:10px;color:var(--ink);font:inherit;font-size:13px;caret-color:var(--blue)}
.registry-controls input::placeholder{color:var(--muted)}
.registry-controls input:focus-visible,.registry-controls select:focus-visible,.registry-scroll:focus-visible{outline:3px solid #b88b17;outline-offset:3px}
.registry-controls>button{grid-column:1/-1;justify-self:start;border:0;background:transparent;padding:7px 0;color:var(--blue);font-size:12px;cursor:pointer;text-decoration:underline;text-underline-offset:4px;min-height:40px}
#registry-results{font-size:12px;color:var(--muted);font-variant-numeric:tabular-nums}
.registry-scroll{width:100%;overflow:auto;margin:0 0 18px;scrollbar-color:#91adc8 #edf5fb;scrollbar-width:thin}
.registry-table{width:100%;border-collapse:collapse;table-layout:fixed;min-width:780px;font-size:12px;line-height:1.6;text-align:left}
.registry-table caption{text-align:left;padding:0 0 14px;color:var(--muted);font-size:12px}
.registry-table th{background:var(--blue);color:#fff;padding:13px 10px;font-weight:600;vertical-align:top}
.registry-table th:first-child{width:25%}.registry-table th:nth-child(2){width:22%}.registry-table th:nth-child(3){width:16%}.registry-table th:nth-child(4){width:12%}.registry-table th:nth-child(5){width:12%}.registry-table th:nth-child(6){width:13%}
.registry-table td{padding:15px 10px;border-bottom:1px solid var(--line);vertical-align:top;overflow-wrap:anywhere;font-variant-numeric:tabular-nums}
.registry-table tbody tr:nth-child(even){background:#f5f8fb}
.registry-table td:first-child{font-weight:600;color:var(--dark)}
.registry-status{display:inline-block;font-size:11px;line-height:1.5;padding:4px 7px;border-radius:4px;font-weight:500}
.has-registration{background:#e2eff7;color:#174675}.pending-registration{background:#fff0cf;color:#755615}
.registry-pagination{display:flex;gap:16px;justify-content:space-between;align-items:center;margin-bottom:24px}
.registry-pagination button{font:inherit;font-size:12px;padding:10px 16px;border:1px solid #c3d2e0;border-radius:5px;background:white;color:var(--blue);min-height:44px;cursor:pointer}
.registry-pagination button:hover:not(:disabled){background:var(--pale)}
.registry-pagination button:disabled{background:#f2f5f7;color:#728190;cursor:default}
.registry-pagination span{font-size:12px;color:var(--muted)}
.registry-empty{background:#fff8e8;padding:18px;border-radius:5px}
@media(max-width:700px){.registry-controls{grid-template-columns:minmax(0,1fr) minmax(0,1fr);padding:16px}.registry-search{grid-column:1/-1}}
@media(max-width:600px){
 .registry-scroll{overflow:visible}.registry-table{display:block;min-width:0;table-layout:auto}
 .registry-table caption{display:block;font-size:12px;line-height:1.7}
 .registry-table thead{position:absolute;width:1px;height:1px;overflow:hidden;clip:rect(0,0,0,0);white-space:nowrap}
 .registry-table tbody{display:block}.registry-table tbody tr{display:block;border:1px solid var(--line);border-radius:10px;margin-bottom:14px;padding:14px;background:#fff}
 .registry-table tbody tr:nth-child(even){background:#f5f8fb}
 .registry-table td{display:block;padding:6px 0;border:0;line-height:1.7;font-size:13px}
 .registry-table td:before{content:attr(data-label);display:block;color:var(--muted);font-size:11px;font-weight:500;line-height:1.6;margin-bottom:2px}
 .registry-table td:first-child{font-size:14px}.registry-table td:first-child:before{display:none}
 .registry-status{font-size:12px}.registry-pagination{gap:8px}.registry-pagination button{padding:10px 12px}
}



.source-criteria{font-size:15px;line-height:1.8;padding-left:22px}.source-criteria li{margin:8px 0}

.pharmacovigilance-actions{display:flex;align-items:center;justify-content:space-between;gap:28px;margin-top:24px}.report-qr{margin:0;text-align:center;flex:0 0 180px}.report-qr img{display:block;width:180px;height:180px;max-width:100%;margin:0 auto;background:#fff;border-radius:6px}.report-qr figcaption{font-size:12px;line-height:1.7;margin-top:10px}.report-qr figcaption span{font-size:11px}.pharmacovigilance .button{white-space:normal;text-align:center}
@media(max-width:600px){.pharmacovigilance-actions{flex-direction:column;align-items:flex-start;gap:24px}.report-qr{align-self:center;flex-basis:auto}.pharmacovigilance .button{max-width:100%}}